The American College of Pediatricians issued a statement in January articulating concerns about the Gardasil Human Papillomavirus Vaccine (HPV4). Two reports have been issued, each highlighting 3 cases, where post-menarcheal adolescent girls developed laboratory documented premature ovarian failure within weeks to several years of receiving the Gardasil vaccine. Premature ovarian failure, (POF), is also known as premature menopause.
Since Gardasil was licensed in 2006, there have been 213 reports to the Vaccine Adverse Event Reporting System (VAERS) of premature menopause, 88% of which have be associated with Gardasil. The report from the American College of Pediatricians is concerned that about the failure to test for POF in the vaccines original studies, both rat and human trails. There is further concern that because most primary care physicians are unaware of the possible association between HPV4 and POF, there may be a failure to report cases of POF to the Vaccine Adverse Event Reporting System. This study further notes that during the pre-HPV vaccine period from 1990 to 2006, no cases of POF or premature menopause were reported to VAERS.
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